Dana is surprised when a former beauty queen asks her to perform a surgery on her that she thinks will make her husband believe that she's beautiful; Lu overreacts when accuses a former drug addict of using again, but it is later discovered she has a very serious medical condition; Peter doesn't understand why a transvestite is having side effects of menopause and he also counsels Lu's son, Marc about one of the issues of male adolescence; Lu and Lana figure out a way to punish two teenagers who spray-painted graffiti on the inside of the clinic.
In the middle of a crushing heat wave, Andy is confronted with the ethical dilemma of whether to help a single woman, pre-destined to have early Alzheimer's disease, have a baby. Also, Lu fights to save a sixteen-year old girl who has been shot in a gang initiation and finds out the truth about a mother who turns in her daughter with Downs Syndrome as the perpetrator of the shooting. Andy struggles with introducing Dr. Milo Morton to her daughters. Elsewhere, Andy and Milo stop a baby's heart in the fight to save its life.
Andy tells Amber Seale, a famous rock star, and a patient to rest and cancel some of her concerts because of fatigue. The rock star invites Lu's young patient Lily who has a terminal disease to spend the day with her. Lu's patient's mother directs a terrible accusation at the rock star. Ben starts a concierge service to keep the clinic open after it faces financial difficulties.
Lu tries to help injured single mom, Melissa Nauls, who's addicted to Crystal Meth keep custody of her three kids. But when Melissa dies after going back to a crystal meth lab Lu has to find a way to keep all three kids together as Christmas approaches. Meanwhile, Kayla is attracted to blind patient Will Manning which makes Peter very jealous.